Development of a Microscopic Traffic Simulator for Inter-Vehicle Communication Application Research

This paper describes the development of a microscopic traffic simulator purposely designed for ITS researchers studying inter-vehicle communication (IVC) concepts and applications in large traffic networks. The simulator can represent real life vehicles within the simulation by using data from vehicle Global Positioning System (GPS) receivers, enabling validation of theories with real vehicle data. The software is developed on top of the existing microscopic traffic simulator VISSIM with the added flexibility of modelling and efficiently handling communication between large numbers of vehicles. This along with the software architecture was discussed in detail

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Distributed Platoon Assignment and Lane Selection for Traffic Flow Optimization

This paper presents an approach to lane assignment for highway vehicles that increases traffic throughput while ensuring vehicles can exit successfully at their destinations. To enhance traffic safety and increase lane capacities, vehicles can be organized into platoons with the objective of maximizing the travel distance that platoons stay intact and then apply lane assignment to these platoons. The goal of this research is to form a distributed control strategy to select lanes for platoons using inter-vehicle communication. We evaluate the current platoon lane assignment strategy and compare its improvement over average vehicle travel time with the lane assignment for single vehicles reported in our previous work. Simulation results show that while cooperate control for single vehicle lane assignment does lead to decreased vehicle travel times, the implementation of cooperative lane assignment for platooning vehicles leads to an even greater reduction

Optimized Lane Assignment Using Inter-Vehicle Communication

This paper presents an approach to lane assignment for highway vehicles that increases traffic throughput while ensuring they exit successfully at their destinations. Most of current traffic management systems do not consider lane organization of vehicles and only regulate traffic flows by controlling traffic signals or ramp meters. However, traffic throughput and efficient use of highways can be increased by coordinating driver behaviors intelligently. The goal of this research is to form a distributed control strategy for cars themselves to select lanes using inter-vehicle communication. Initial results are promising and demonstrate that intelligent lane selection can decrease vehicle traffic time

Realtime Experiments in Markov-Based Lane Position Estimation Using Wireless Ad-Hoc Network

This paper presents real-time experimental results for a new lane positioning system using Markov localization based on inter-vehicle communication. The proposed system uses low-cost GPS receivers to provide vehicle locations. The system also combines a low-pass Butterworth filter and a particle filter for GPS receiver noise rejection. To study the new lane positioning system, a multi-threaded program in C++, that enables the communication between vehicles and determines their lane positions in real-time, was developed. Experiments using this software validate the effectiveness of the lane positioning system

Co-operative Lane-Level Positioning Using Markov Localization

The majority of today\u27s navigation techniques for intelligent transportation systems use Global Positioning Systems (GPS) that can provide position information with bounded errors. However, because of the low accuracy and multi-path problem, it is challenging to determine a vehicle\u27s position at lane level. With Markov-based approach based on sharing information among a group of vehicles that are traveling close to each other, the lane positions of vehicles can be found. The algorithm shows its effectiveness in both simulations and experiments with real data

Markov-Based Lane Positioning Using Intervehicle Communication

The majority of today\u27s navigation techniques for intelligent transportation systems use global positioning systems (GPS) that can provide position information with bounded errors. However, due to the low accuracy that is experienced with standard GPS, it is difficult to determine a vehicle\u27s position at lane level. Using a Markov-based approach based on sharing information among a group of vehicles that are traveling within communication range, the lane positions of vehicles can be found. The algorithm\u27s effectiveness is shown in both simulations and experiments with real data